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Stephen L. Aronoff, MD, FACP, FACE

Director, Research Institute of Dallas
Clinical Endocrinologist, Richardson, Texas

Biographical Summary:

Stephen L. Aronoff, MD, received his undergraduate degree from Duke University in Durham, North Carolina and his medical degree with honors from the University of Texas Southwestern Medical School in Dallas, Texas. He did his internship at the Parkland Memorial Hospital in Dallas and his residency in internal medicine at the Barnes Hospital, Washington University School of Medicine in St. Louis, Missouri. He then completed a Fellowship in Metabolism and Endocrinology at the Washington University School of Medicine. After completing his studies, Dr. Aronoff became Chief of the Phoenix Clinical Research Section of the National Institute of Arthritis, Metabolism & Digestive Diseases of the National Institutes of Health in Phoenix, Arizona. He also served as Acting Chief of the Southwest Field Studies Branch of the National Institutes of Health. During both terms of service with the National Institutes of Health, Dr. Aronoff directed research studies that focused on diabetes and obesity.

Dr. Aronoff is a clinical endocrinologist in private practice since 1981 and the Director of the Research Institute of Dallas. He is a board certified specialist in Endocrinology and Metabolism through the American Board of Internal Medicine. Dr. Aronoff is also a Fellow of the American College of Physicians and the American College of Endocrinology, and is a member of the American Association of Clinical Endocrinologists, and the Endocrine Society. He has been an active member in the American Diabetes Association, and has served as president of the Dallas County chapter. He is a past president of the Texas chapter of the American Association of Clinical Endocrinologists. Dr. Aronoff’s research has been published in various books and peer-reviewed journals such as the American Journal of Physiology, The Journal of Clinical Endocrinology and Metabolism, Lancet and the journal Diabetes.

C U R R I C U L U M   V I T A E
STEPHEN L. ARONOFF, M.D., F.A.C.P., F.A.C.E.


Business Address: 2400 Lakeside Blvd.
Suite 130
Richardson, TX 75082
Research Institute of Dallas, P.A.
10260 N. Central Expwy., Suite 100N
Dallas, TX 75231
Date of Hire: August 2015
Concierge Practice
August 19, 1994 (Date of Hire)
Business Phone:  (214) 774-4475 (214) 265-2137
Education and Training:  
Graduated in 1964 High School: Thomas Jefferson High School, Dallas, Texas
1964 - 1968 College: Duke University, B.A. Chemistry
1968 - 1972 Medical School: University of Texas at Dallas Southwestern Medical School
Internship and Residency:  
1972 - 1973 Internship in Internal Medicine, Parkland Memorial Hospital, Dallas, Texas
1976 - 1977 Residency in Medicine, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri
Fellowship:  
1977 - 1979 Fellowship in Metabolism and Endocrinology, Washington University School of Medicine, St. Louis, Missouri
License: Texas State Board of Medical Examiners
Employment:  
August 2015 - Present Stephen L. Aronoff, M.D., P.L.L.C.
2400 Lakeside Blvd., Suite 130
Richardson, TX 75082
1983 - 2015 Clinical Endocrinologist
Endocrine Associates of Dallas
10260 N. Central Expressway Suite 100 N
Dallas, Texas 75231
1994 – Present Director Research Institute of Dallas
10260 N. Central Expressway Suite 100 N
Dallas, Texas 75231
1981 - 1983 Clinical Endocrinologist
Phoenix Endocrinology Clinic
555 W. Catalina, Suite 11
Phoenix, Arizona 85013
1979 - 1981 Chief, Phoenix Clinical Research Section
Acting Chief, Epidemiology and Field Studies Branch
National Institute of Health - NIAMDD
4212 North 16th Street
Phoenix, Arizona 85016
1973 - 1976 Staff Associate
Southwestern Field Studies Section
NIH, NIAMDD Phoenix, Arizona
Appointments:  
1983 - 2015 Clinical Associate Professor of Medicine, University of Southwestern Medical School at Dallas
Honors:  
1972 Alpha Omega Alpha, UTSMS
1971 University of Texas Scholastic Award
1972 Pfizer Scholastic Award
Certifications:  
1978 American Board of Internal Medicine, Board Certification
1979 American Board of Internal Medicine, Endocrinology and Metabolism Subspecialty
Research Experience:
1964, 1965, 1966, 1968
(Summer)
Research Technician at Sammons Research Center,
Baylor University Medical Center at Dallas
Director: James W. Finney, Ph.D.
  Studies included investigation of tumor antibodies in animals, effects of hydrogen peroxide on atherosclerotic plaques, localization of radioisotopes in tumors by local perfusion of hydrogen peroxide, and prolongation of myocardial muscle viability following coronary artery occlusion by systemic hydrogen peroxide infusion.
1969
(Spring and Summer)
University of Texas Southwestern Medical School Department of OB-GYN under Paul McDonald, M.D. and P. Siteri, Ph.D.

Work included studies of competitive protein binding of estrogen and radioimmunoassay of estrogen

1971
(Summer)
University of Texas Southwestern Medical School Department of Medicine,
Renal Division under Donald W. Seldin, M.D. and Floyd C. Rector, Jr., M.D.

Studies included effect of bicarbonate on free water formation in the dog kidney and antibody formation to glomerular basement membrane and proximal tubular brush border.

July 1973 to July 1976 Staff Associate - NIAMDD - SFSS, Phoenix, Arizona under Peter H. Bennett, M.D., F.R.C.P., F.F.C.M.

Major portion of time spent on organizing and conduction studies on approximately 150 prediabetic, diabetic and normal Pima Indians and normal Caucasians. Studies included Oral GTT, IV, GTT, Arginine Infusion, Cortisone GTT, muscle biopsy for basement membrane thickness determination, urine studies of specific urinary proteins and volatile organic compounds, skin biopsies for fibroblast culture.

Other work included Medical Officer-in-Charge of Sacaton Clinic involving collection of data on diabetes and arthritis in the Pima Indian epidemiologic study.

1977 to 1979 Research Fellow, Metabolism Division Department of Medicine with Dr. David M. Kipnis

Clinical Fellow with Dr. William H. Daughaday

1979 to 1981 Chief, Phoenix Clinical Research Section; Acting Chief Epidemiology and Field Studies Branch, National Institute of Health, Phoenix, Arizona
1983 to 2015 Clinical Endocrinologist, Investigator, Endocrine Associates of Dallas, Dallas, Texas
1995 to present Medical Director, Investigator, Research Institute of Dallas, Dallas, Texas
Memberships:  
Fellow, American College of Physicians

Fellow, American College of Endocrinologists

American Association of Clinical Endocrinologists

Endocrine Society

American Medical Association

Dallas County Medical Society

Texas Medical Association

American Diabetes
Association President, Dallas County Chapter, 1985 - 1988
Member, Development Committee
Texas Affiliate

Juvenile Diabetes Foundation
Member, Professional Advisory Board
Member, Board of Directors
Dallas Chapter

PUBLICATIONS

ABSTRACTS:

Aronoff, S.L., Bennett, P.H., Savage, P.J., Unger, R.H., and Miller, M.: Glucagon Response to Arginine in Prediabetic and Normal Pima Indians and Normal Caucasians. Clinical Research 23: 418A, April, 1975

Aronoff, S.L., Bennett, P.H., and Gordon, P.: Early Phase Insulin Release to IV Glucose in Prediabetic and Normal Pima Indians and Normal Caucasians. Diabetes 24, (Suppl. 12) 402, 1975

Aronoff, S.L., Bennett, P.H., and Williamson, J.R., Siperstein, M.D., Plumer, M.D., and Miller M.: Muscle capillary basement membrane (CBM) Measurements in Prediabetic, Diabetic and Normal Pima Indians and Normal Caucasian. Clinical Research 24, 455A, April, 1976

Aronoff, S.L., Miller, M., and Harris, V.: Glucagon Suppression in Response to Intravenous Glucose in Normal, Prediabetic and Diabetic Pima Indians. Diabetes 25 (Suppl. 1) 352, 1996

Aronoff, S.L., Bennett, P.H., Siperstein, M.D., and Williamson, J.R.: Muscle Capillary Basement Membrane Thickening in Prediabetic and Diabetic Pima Indians. A Comparison of Techniques. Presented before the First International Symposium on the Biology and Chemistry of Basement Membranes, Philadelphia, November 1976

Schnider, S., Aronoff, S.L., Tchow, P., Miller, M., and Bennett, P.H.: Urinary Protein Excretion in Prediabetic, Normal and Diabetic Pima Indians and Normal Caucasians. Diabetes 26 (Suppl. 1)

Aronoff, S.L., and Kipnis, D.M.: Effect of Indomethacin (INDO) on Insulin Secretion by Cultured-Perifused Rat Islets. Diabetes 27 (Suppl. 2) 457, 1978

Hidaka, H., Klimes, I., Sasaki, H., Aronoff, S.L. and Nagulesparan, M.: Improvement of Insulin Secretion But Not Insulin Sensitivity After Short Term Control of Plasma Glucose in Obese Type II Diabetes. Endocrine Society, 63rd Annual Meeting, p. 150, June, 1981

Knowler, W.C., Savage, P.J., Nagulesparan, M. Howard, V.V., Pettitt, D.J., Aronoff, S.L. and Bennett, P.H.: Obesity, Insulin Resistance and Diabetes Mellitus in the Pima Indians. Diabetologia, Vol. 21, 1981

Klimes, I., Mott, D.M., Nagulesparan, M. and Aronoff, S.L.: Decreased NA+, K+-ATPase Activity Erythrocyte Membrane and Intact Erythrocytes from Obese Man. Diabetes Vol. 30 (Suppl. 1), P. 126A, 1981

Klimes, I., Nagulesparan, M., Hidaka, H., Vasquez, B., Aronoff, S.L. and Unger, R.H.: Endogenous Insulin Secretion During Euglycemic Clamp at Varying Levels of Hyperinsulinemia in Lean and Obese Subjects. Presented at the 17th Annual Meeting of the European Association For the Study of Diabetes. Amsterdam, September 15-18, 1981

Aronoff, S., Saini, R., Guthrie, R., Rosenblatt, S.: Neurohormonal Effects of Vasopeptidase Inhibition with Omapatrilat in Hypertension. Presented at the American College of Cardiology, 2000.

Aronoff, S.L.: Clinical Experience: Amylin Hormone Replacement in Patients with Diabetes. Presented at the American Association of Clinical Endocrinologists National Meeting, May 2003

Aronoff, S.L.: A Complement to Insulin: Clinical Data Exploring Pramlintide Use in Type 2 Diabetes. Presented at the American Association of Clinical Endocrinologists National Meeting, April 2004

Aronoff, S.L.: Amylin Replacement Therapy for Patients with Insulin-Requiring Type 2 Diabetes. Presented at the American Diabetes Association’s 65th Scientific Sessions, June 2005

Aronoff, S.L.: Clinical Data Indicate Early, Aggressive treatment Can Improve Glycemic and Vascular Outcomes in Type 2 Diabetes. Presented at the American Clinical Nurse Practioner National Clinical Conference, October 2006

Aronoff, S.L.: Pathophysiology of Diabetes Mellitus: A Physiologic Multihormonal Approach to Treatment. Presented at the American Diabetes Association’s 67th Scientific Sessions, June 2007

Aronoff, S.L.: Pancreatic Hormones Insulin and Amylin Working Together. Presented at the Annual Meeting of the American Association of Diabetes Educators, August 2008

MANUSCRIPTS:

Wallin, J.P., Brennen, J.P., Long, D.L., Aronoff, S.L., Rector, F.C. Jr., and Seldin, D.W.: Effect of Increased Distal Bicarbonate Delivery on Free Water Re-Absorption in the Dog. Am. J. Physiol. 224 (1):209-218, 1973

Aronoff, S.L., Bennett, P.H., Rushforth, N.B., Miller, M., and Unger, R.H.: Arginine-Stimulated Hyperglucagonemia in Diabetic Pima Indians. Diabetes 25: 404-407, May, 1976

Aronoff, S.L., Bennett, P.H., Rushforth, N.B., Miller M., and Unger, R.H.: Normal Glucagon Response to Arginine Infusion in “Prediabetic” Pima Indians. J. Clin. Endocrinol. Metab. 43: 279-286, 1976

Bennett, P.H., Aronoff, S.L., Unger, R.H.: Evidence for an Insulin-Dependent Alpha-Cell Abnormality in Human Diabetes. Metabolism, Vol. 25 (Suppl. 1), 1527-1529, 1976

Aronoff, S.L., Bennett, P.H., and Unger, R.H.: Immunoreactive Glucagon (IRG) Response to Intravenous Glucose in Prediabetes and Diabetes Among Pima Indians and Normal Caucasians. J. Clin. Endocrinol. Metab. 44: 968-972, 1977

Aronoff, S.L., Bennett, P.H., Gordon, P., Rushforth, N.B., and Miller, M.: Unexplained Hyperinsulinemia in Normal and “Prediabetic” Pima Indians Compared to Normal Caucasians. An Example of Racial Differences in Insulin Secretion. Diabetes 26: 827-840, 1977

Gingerich, R.L., Aronoff, S.L., Kipnis, D.M. and Lacy, P.E.: Insulin and Glucogon Secretion From Rat Islets Maintained in a Tissue Culture-Perifusion System. Diabetes 28: 282-286, 1979

Aronoff, S.L., Passamani, E., Borowsky, B.A., Weiss, A.N., Roberts, R., and Cryer, P.E.: Norepinephrine and Epinephrine Secretion From a Clinically Epinephrine Secreting Pheochromocytoma. American J. Med. 69: 231-324, 1980

Aronoff, S.L., Schnider, S., Smeltzer, J., McKay, W., Chow, P., Rushforth, N., Miller, M., and Bennett, P.H.: Urinary Excretion and Renal Clearance of Specific Plasma Proteins in Diabetes of Short and Long Duration. Diabetes 30: 656-663, 1981

Knowler, W.C., Savage, P.J., Nagulesparan, M., Howard, B.V., Pettitt, D.J., Lisse, J.R., Aronoff, S.L., and Bennett, P.H.: Obesity, Insulin Resistance, and Diabetes Mellitus in the Pima Indians. In, Tattersall, R.B., and Kobberling, J. Eds. Proceedings of the 2nd International Conference on the Genetics of Diabetes Mellitus, Freiburg, Germany, Academic Press, Nottingham, England, 1981

Hidaka, H., Nagulesparan, M., Klimes, I., Clark, R., Sasaki, H., Aronoff, S.L., Vasquez, B., Rubenstein, A.H., and Unger, R.H.: Improvement of Insulin Secretion but not Insulin Resistance After Short Term Control of Plasma Glucose in Obese Type II Diabetics. J. Clin. Endocrin. and Metab. 54: 721-274, 1982

Klimes, I., Mott, D.M., Nagulesparan, M., Unger, R.H., Aronoff, S.L.: Reduced Na+, K+ATPase Activity in Intact Red Cells and Isolated Membranes From Obese Man. J. Clin. Endocrin. and Metab. 54: 721-274, 1982

Dorfman, S., Feld, S., Sachson, R., Aronoff, S.: Painless Thyroiditis and Transient Hyperthyroidism. Dallas Medical Journal Vol. 69: 243-246, 1983

Aronoff, S.L., Feld, S., Sachson, R., Dorfman, S., and Colgin, J.: Diabetes Education - An Essential Part of Modern Treatment of the Diabetic. Dallas Medical J. 72: 85-87, 1986

Dorfman, S., Feld, S., Sachson, R., Aronoff, S.: Antithyroid Drugs: Propylthiouracil Versus Methimazole, Dallas County Medical Society Journal 71: 91-95, 1985

Aronoff, S.L.: Therapeutic Options in Established Osteoporosis, in New Strategies in the Management of Established Osteoporosis, pp 20-22, 1989

Aronoff, S.L.: Theraperutic Options in Male Osteoporosis, in New Strategies in the Management of Established Osteoporosis, pp 24-26, 1989

Sachson, R., Feld, S., Dorfman, S.G., Aronoff, S.L.: Osteoporosis and the Spine in Sports: The Benefit of Exercise, in Spine: State of the Art Reviews 4(2): 310-324, May 1990

Aronoff, S., Goldberg, R., Kumar, D., Lichtenstein, E., Schwartz, S., an Sosenko, J.: Use of a Premixed Insulin Regimen (Novolin 70/30) to Replace Self-Mixed Insulin Regimens. Clinical Therapeutics Vol. 16, No. 1, Excerpta Medica, Inc., 1994

Aronoff, S., Rosenblatt, S., Braithwaite, S. et al: Pioglitazone Hydrochloride Monotherapy Improves Glycemic Control in the Treatment of Patients With Type 2 Diabetes. Diabetes Care 23: 1605-1611, 2000

McClellan W, Aronoff SL, Bolton WK, Hood S, Lorber DL, Tang KL, Tse TF, Wasserman B, and Leiserowitz M.: The prevalence of anemia in patients with chronic kidney disease. Curr Med Res Opin.; 20(9):1501-1510, 2004

Aronoff, S.L., Berkowitz, K., Shreiner, B., Want, L.: Glucose Metabolism and Regulation: Beyond Insulin and Glucagon. Diabetes Spectrum 17(3): 183-190, 2004

Habener, J.F., Drucker, D.J., Aronoff, S.L.: 3 Perspectives on New Type 2 Diabetes Treatment. Recent Advances in the GLP-1 Pathway. Endocrine News, pp 16-26, June 2007

Heerspink HL, Greene T, Lewis JB, Raz I, Rohde RD, Hunsicker LG, Schwartz SL, Aronoff S, Katz MA, Eisner GM, Mersey JH and Wiegmann TB: Effects of Sulodexide in Patients with Type 2 Diabetes and Persistent Albuminuria. Nephrol Dial Transplant 0: 1-9 (2007) 

Thomas Blevins, MD, Sherwyn L. Schwartz, MD, Bruce Bode, MD, Stephen Aronoff, MD, Claire Baker, MD, Kay T. Kimball, PhD, Ronald B. Harrist, PhD, Chris Donnelly, Lauren C. Burns, and Anna M. Wooldridge: A Study Assessing an Injection Port for Administration of Insulin. Diabetes Spectrum 21: 197-202, 2008

Thomas Blevins, MD, Jenny Han, MS, Dawn Nicewarner, PhD, Steve Chen, MD, Juliana H. A. Oliveira, MD, PhD, Stephen Aronoff, MD; Exenatide is Non-inferior to Insulin in Reducing HbA1c: An Integrated Analysis of 1423 Patients with Type 2 Diabetes. Postgraduate Medicine, Volume 122, Issue 3, May 2010

Nicole Sherry, MD, William Hagopian, MD, Johnny Ludvigsson, MD, Sunil M Jain, MD, Jack Wahlen, MD, Robert J Ferry, MD, Bruce Bode, MD, Stephen Aronoff, MD, Christopher Holland, MS, et. al.: Teplizumab for Treatment of Type 1 Diabetes (Protégé Study): 1-year Results from a Randomised, Placebo-controlled Trial. The Lancet, Volume 378, Issue 9790, pp. 487-497, August 6, 2011.

           

 

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